First get a photo of a person you want to transform.
Now goto Filter>>Liquify. Use the bloat tool to highlight various areas of the face. Just experiment with all the tools. In this picture I blew up Jay Leno's chin, hair, and eyes.
Next goto Filter>>Artistic>>Poster Edges. Set edge thickness to 0, edge intensity to 2, and posterization to 6. These settings can vary, but those were the settings I used. Wasn't that simple?